^ 'Mass school overdose investigation focuses on banned Russian drug'.^ Administration, Australian Government Department of Health.8.) EMMI rendelet Az új pszichoaktív anyaggá minősített anyagokról vagy vegyületcsoportokról szóló 55/2014. 'Effect of Phenibut and Glufimet, a Novel Glutamic Acid Derivative, on Respiration of Heart and Brain Mitochondria from Animals Exposed to Stress against the Background of Inducible NO-Synthase Blockade'. ^ Perfilova VN, Popova TA, Prokofiev II, Mokrousov IS, Ostrovskii OV, Tyurenkov IN (June 2017).'Novel psychoactive substances of interest for psychiatry'. ^ Schifano F, Orsolini L, Duccio Papanti G, Corkery JM (2015).'Optical isomers of phenibut inhibit -Gabapentin binding in vitro and show activity in animal models of chronic pain'. ^ a b c d Belozertseva I, Nagel J, Valastro B, Franke L, Danysz W (2016).'The neuroprotective effects of R-phenibut after focal cerebral ischemia'. ^ Vavers E, Zvejniece L, Svalbe B, Volska K, Makarova E, Liepinsh E, Rizhanova K, Liepins V, Dambrova M (2016).'The Effects of Agonists of Ionotropic GABAA and Metabotropic GABAB Receptors on Learning'.
'A new synthesis resolution and in vitro activities of (R)- and (S)-β-Phenyl-Gaba'. 'Comparative pharmacological activity of optical isomers of phenibut'.
^ a b Dambrova M, Zvejniece L, Liepinsh E, Cirule H, Zharkova O, Veinberg G, Kalvinsh I (2008). ^ a b GABAb Receptor Pharmacology: A Tribute to Norman Bowery: A Tribute to Norman Bowery. 'Characteristics of GABAB receptor binding sites on rat whole brain synaptic membranes'. ^ Bowery NG, Hill DR, Hudson AL (1983). Chemistry and pharmacology of GABAB receptor ligands. 'R-phenibut binds to the α2-δ subunit of voltage-dependent calcium channels and exerts gabapentin-like anti-nociceptive effects'. ^ a b c d e f g h i Zvejniece L, Vavers E, Svalbe B, Veinberg G, Rizhanova K, Liepins V, Kalvinsh I, Dambrova M (2015). 'Phenibut (β-Phenyl-GABA): A Tranquilizer and Nootropic Drug'. 'Phenibut (beta-phenyl-GABA): A tranquilizer and nootropic drug'. 
^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac Lapin, I.^ a b c d e f g h i j k l m n o p q r s t u Ozon Pharm, Fenibut (PDF), retrieved 15 September 2017.The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 'Phenibut (4-amino-3-phenyl-butyric acid): Availability, prevalence of use, desired effects and acute toxicity'.
^ a b c d e f g h i j k l m n o p q r s t u v w x y z Owen DR, Wood DM, Archer JR, Dargan PI (2016). Īs of 14 November 2018, Hungary added phenibut and 10 other items to its New Psychoactive Substances ban list. For this reason, the actions of phenibut as a α 2δ subunit-containing voltage-gated calcium channel blocker or gabapentinoid may be its true primary mechanism of action, and this may explain the differences between phenibut and its close relative baclofen (which, in contrast, has essentially insignificant activity as a gabapentinoid K i = 6 μM for the GABA B receptor and K i = 156 μM for α 2δ subunit-containing VDCCs, or a 26-fold difference in affinity). As such, based on the results of this study, phenibut would appear to have much greater potency in its interactions with α 2δ subunit-containing VDCCs than with the GABA B receptor (between 5- to 10-fold). Moreover, ( R)-phenibut possesses 4-fold greater affinity for this site than for the GABA B receptor (K i = 92 μM), while ( S)-phenibut does not bind significantly to the GABA B receptor (K i > 1 mM). Both ( R)-phenibut and ( S)-phenibut display this action with similar affinity (K i = 23 and 39 μM, respectively). Phenibut also binds to and blocks α 2δ subunit-containing VDCCs, similarly to gabapentin and pregabalin, and hence is a gabapentinoid.
0 kommentar(er)
